참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sulfite | HCID 1099 | — |
| 반응물 | 1,4,5,8-Naphthalenetetracarboxylic acid | HCID 31422 | — |
| 반응물 | [2-adenin-9-yl-5-[[[[5-(3-carbamoyl-4H-pyridin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxymethyl]-4-hydroxy-tetrahydrofuran-3-yl] phosphate | HCID 12598259 | — |
| 생성물 | 1,4,5,8-Naphthalenetetracarboxylic acid | HCID 31422 | — |
| 생성물 | Disodium | HCID 141233 | — |
반응 단계
The process as claimed in claim 9, wherein, after the oxidation has ended, the reaction mixture is subjected to a heat treatment at a temperature of between 90° and 100° C. under the autogenous pressure of 1 to 5 bar which is established, in the presence of sulfite, the resulting suspension of the tetrasodium salt of naphthalene-1,4,5,8-tetracarboxylic acid is cooled, after the reaction vessel has been let down, to a temperature of 20° to 30° C. the pH is then adjusted to 4.5 to 5 by acidification, the resulting disodium salt of naphthalene-1,4,5,8-tetracarboxylic acid is isolated, this salt is converted into the tetrasodium salt of naphthalene-1,4,5,8-tetracarboxylic acid in an aqueous alkali metal hydroxide solution and, optionally after removal of insoluble impurities, naphthalene-1,4,5,8-tetracarboxylic acid 1,8-monoanhydride is precipitated by acidification to a pH of less than 1 at a temperature of 80° to 100° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05254796 |
|---|
| 출처 데이터셋 | uspto-grants-1993_10 |
|---|
| ORD ID | ord-6b19443ace4141118d6eedec8f96c519 |
|---|
| 출처 메모 | uspto-grants-1993_10 |
|---|
