phenylalaninol, (R)- → HCID 15667126, 화합물

HRID 1656903

반응식

HRID 1656903 반응식
[C:1]1([N:7]2[C:11]3=[N:12][C:13]([Cl:17])=[N:14][C:15](Cl)=[C:10]3[CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:18][C@H:19]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:20][OH:21]>C(O)C>[C:1]1([N:7]2[C:11]3=[N:12][C:13]([Cl:17])=[N:14][C:15]([NH:18][C@H:19]([CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:20][OH:21])=[C:10]3[CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 853475phenylalaninol, (R)-HCID 47371094,6-dichloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine

생성물 1

HCID 15667126HCID 15667126, 화합물수율 95%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

First, 2.81 g of 1-phenyl-4,6-dichloropyrazolo[3,4-d]pyrimidine was suspended in 60 ml of ethanol, then 3.2 g of (R)-(+)-2-amino-3-phenyl-1-propanol was added with stirring. After 48 hours the solvent was removed under vacuum and the oil was flash chromatographed (2-5-7% MeOH/CHCl3) to yield 3.80 g of (R)-β-[(1-phenyl-6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzenepropanol (95%).

후처리

  1. customAfter 48 hours the solvent was removed under vacuum
  2. customchromatographed (2-5-7% MeOH/CHCl3)

출처 및 근거

ORD 기록
ord-1e9b0988c1a84a3da289705a40bd47c6
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05256650

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