Ethanol → 2-Formylamino-4-(4-aminophenylthiomethyl)thiazole

HRID 1656971노트

반응식

HRID 1656971 반응식
[CH:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([CH2:9][S:10][C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=2)[N:8]=1)=[O:2].[Cl-].[NH4+].C(O)C.O>O1CCCC1.[Fe]>[CH:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([CH2:9][S:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)[N:8]=1)=[O:2]

참가 물질

7

반응물 4

HCID 702EthanolHCID 962WaterHCID 25517Ammonium ChlorideHCID 15729170HCID 15729170, 화합물

생성물 1

HCID 157291712-Formylamino-4-(4-aminophenylthiomethyl)thiazole수율 81%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a mixture of 2-formylamino-4-(4-nitrophenylthiomethyl)thiazole (2.2 g) and ammonium chloride (0.5 g) in a mixture of tetrahydrofuran (30 ml), ethanol (50 ml) and water (10 ml) was added portionwise the iron powder at 80° C. with stirring. The mixture was refluxed for 2 hours with stirring. The reaction mixture was filtered by suction and the residue was triturated with water. The precipitates were collected by filtration, washed with water and dried in vacuo to give 2-formylamino-4-(4-aminophenylthiomethyl)thiazole (1.6 g, yield: 81%). mp: 180°-182° C.

후처리

  1. temperatureThe mixture was refluxed for 2 hours
  2. stirringwith stirring
  3. filtrationThe reaction mixture was filtered by suction
  4. customthe residue was triturated with water
  5. filtrationThe precipitates were collected by filtration
  6. washwashed with water
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-8edd794016874f1ba35246534b43a515
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05256675

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