Sodium Chloride → HCID 19787485, 화합물

HRID 1657280노트

반응식

HRID 1657280 반응식
[OH-].[K+].O1CCCC1.[O:8]=[C:9]([CH3:20])[CH2:10][C:11]([CH:17]1[CH2:19][CH2:18]1)([CH:14]1[CH2:16][CH2:15]1)[CH:12]=O.[Cl-].[Na+]>C(OCC)C>[CH:14]1([C:11]2([CH:17]3[CH2:19][CH2:18]3)[CH2:10][C:9](=[O:8])[CH:20]=[CH:12]2)[CH2:16][CH2:15]1

참가 물질

6

반응물 4

HCID 5234Sodium ChlorideHCID 8028TetrahydrofuranHCID 14797Potassium HydroxideHCID 19787455HCID 19787455, 화합물

생성물 1

HCID 19787485HCID 19787485, 화합물수율 91.6%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a mixture of 5% aqueous solution of potassium hydroxide (4.7 ml) and tetrahydrofuran (4.7 ml) was added a solution of 4-oxo-2,2-dicyclopropylpentanal (1.88 g) in diethyl ether (9.4 ml). The mixture was heated at 38° C. to 45° C. for 3 hours and cooled. The aqueous layer was saturated with sodium chloride. The mixture was extracted with diethyl ether and the extract was washed with brine, dried over sodium sulfate, and evaporated in vacuo. The residue was purified by distillation under reduced pressure to give 4,4-dicyclopropyl-2-cyclopenten-1-one (1.55 g).

후처리

  1. temperatureThe mixture was heated at 38° C. to 45° C. for 3 hours
  2. temperaturecooled
  3. extractionThe mixture was extracted with diethyl ether
  4. washthe extract was washed with brine
  5. dry with materialdried over sodium sulfate
  6. customevaporated in vacuo
  7. distillationThe residue was purified by distillation under reduced pressure

출처 및 근거

ORD 기록
ord-49ef4a14f04d4d5a9d77b0cc27590ba9
출처 데이터셋
uspto-grants-1993_10
특허 번호
US05256824

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