Ammonia → 3-Benzyl-1,2,4-oxadiazol-5-amine
반응식
[C:1]1([CH2:7][C:8]2[N:12]=[C:11](C(Cl)(Cl)Cl)[O:10][N:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH3:17]>CCOCC>[NH2:17][C:11]1[O:10][N:9]=[C:8]([CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[N:12]=1참가 물질
4
실험 절차
A mixture of 60 g. (0.22 moles) of 3-(phenylmethyl)-5-trichloromethyl-1,2,4-oxadiazole and 50 ml. of ether are added dropwise with stirring into 100 ml. of liquid ammonia and stirred for an additional hour. The ammonia and ether are evaporated, the residue is treated with a little water and filtered under suction. 33.3 g. of 5-amino-3-(phenylmethyl)-1,2,4-oxadiazole are obtained, m.p. 142°-145°. After recrystallization from ethanol the compound melts at 145°-146°.
후처리
- additionA mixture of 60 g
- customThe ammonia and ether are evaporated
- additionthe residue is treated with a little water
- filtrationfiltered under suction
출처 및 근거
- ORD 기록
- ord-d136b4f85bd549d59d5f959bb3173914
- 출처 데이터셋
- uspto-grants-1976_06
- 특허 번호
- US03960849
반응 노트
불러오는 중…