1-(3-Chlorophenyl)piperazine → 3-[2-(4-m-Chlorophenyl-1-piperazinyl)ethyl]-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one . dihydrochloride

HRID 1657405

반응식

HRID 1657405 반응식
[Cl:1][CH2:2][CH2:3][C:4]1[C:9](=[O:10])[N:8]2[CH:11]=[CH:12][C:13]([CH3:15])=[CH:14][C:7]2=[N:6][C:5]=1[CH3:16].[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[ClH:1].[ClH:17].[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][N:27]([CH2:2][CH2:3][C:4]3[C:9](=[O:10])[N:8]4[CH:11]=[CH:12][C:13]([CH3:15])=[CH:14][C:7]4=[N:6][C:5]=3[CH3:16])[CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1

참가 물질

4

반응물 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 1008613-(2-chloroethyl)-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one

생성물 1

HCID 1317102643-[2-(4-m-Chlorophenyl-1-piperazinyl)ethyl]-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one . dihydrochloride수율 46.2%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 2.4 g of 3-(2-chloroethyl)-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one, 5.9 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed for 30 hours. After completion of the reaction, the rection mixture was then treated in the same manner as in Example 4, and the obtained crude crystals were recrystallized from a mixture of methanol and ethanol to give 2.2 g of the desired compound as pale yellow plates, m.p. 272° - 274°C (decomp.).

후처리

  1. temperaturewas refluxed for 30 hours
  2. customAfter completion of the reaction
  3. additionthe rection mixture was then treated in the same manner as in Example 4
  4. customthe obtained crude crystals
  5. customwere recrystallized from a mixture of methanol and ethanol

출처 및 근거

ORD 기록
ord-6b7c1f244f27470ca6faeedfff4953db
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03960863

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