1-(3-Chlorophenyl)piperazine → 2-Methyl-3-[2-(4-m-chlorophenyl-1-piperazinyl)ethyl]-7-chloro-4H-pyrido[1,2-a]pyrimidin-4-one

HRID 1657408

반응식

HRID 1657408 반응식
[CH3:1][C:2]1[N:3]=[C:4]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:5]2[C:6](=[O:11])[C:7]=1[CH2:8][CH2:9]Cl.[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[CH3:1][C:2]1[N:3]=[C:4]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:5]2[C:6](=[O:11])[C:7]=1[CH2:8][CH2:9][N:27]1[CH2:26][CH2:25][N:24]([C:20]2[CH:21]=[CH:22][CH:23]=[C:18]([Cl:17])[CH:19]=2)[CH2:29][CH2:28]1

참가 물질

4

반응물 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 124149402-methyl-3-(2-chloroethyl)-7-chloro-4H-pyrido[1,2-a]pyrimidin-4-one

생성물 1

HCID 124148552-Methyl-3-[2-(4-m-chlorophenyl-1-piperazinyl)ethyl]-7-chloro-4H-pyrido[1,2-a]pyrimidin-4-one수율 23.7%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 1.3 g of 2-methyl-3-(2-chloroethyl)-7-chloro-4H-pyrido[1,2-a]pyrimidin-4-one, 4.2 g of 1-(m-chlorophenyl)piperazine and 20 ml of toluene was refluxed with heating for 30 hours. After completion of the reaction, the reaction mixture was then treated in the same manner as in Example 8. The crude crystals thus obtained were recrystallized from ethanol to give 0.5 g of the desired compound as pale orangeyellow needles, m.p. 152° - 154°C.

후처리

  1. temperaturewas refluxed
  2. temperaturewith heating for 30 hours
  3. customAfter completion of the reaction
  4. additionthe reaction mixture was then treated in the same manner as in Example 8
  5. customThe crude crystals thus obtained
  6. customwere recrystallized from ethanol

출처 및 근거

ORD 기록
ord-d081f29e65a146458b38aa8691e1d098
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03960863

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