1-(3-Chlorophenyl)piperazine → HCID 12414814, 화합물

HRID 1657410노트

반응식

HRID 1657410 반응식
Cl[CH2:2][CH2:3][C:4]1[C:9](=[O:10])[N:8]2[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:7]2=[N:6][C:5]=1[CH3:16].[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1>C1(C)C=CC=CC=1>[Cl:17][C:18]1[CH:19]=[C:20]([N:24]2[CH2:29][CH2:28][N:27]([CH2:2][CH2:3][C:4]3[C:9](=[O:10])[N:8]4[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:7]4=[N:6][C:5]=3[CH3:16])[CH2:26][CH2:25]2)[CH:21]=[CH:22][CH:23]=1

참가 물질

4

반응물 2

HCID 13551-(3-Chlorophenyl)piperazineHCID 124149363-(2-Chloroethyl)-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one

생성물 1

HCID 12414814HCID 12414814, 화합물수율 40.7%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 2.2 g of 3-(2-chloroethyl)-2,7-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one, 4.5 g of 1-(m-chlorophenyl)piperazine and 25 ml of toluene was refluxed for 30 hours. After completion of the reaction, the reaction mixture was then treated in the same manner as in Example 10. The crude crystals thus obtained were recrystallized from a mixture of ethanol and n-hexane to give 1.5 g of the desired compound as pale yellow powders, m.p. 127° - 128°C.

후처리

  1. temperaturewas refluxed for 30 hours
  2. customAfter completion of the reaction
  3. additionthe reaction mixture was then treated in the same manner as in Example 10
  4. customThe crude crystals thus obtained
  5. customwere recrystallized from a mixture of ethanol and n-hexane

출처 및 근거

ORD 기록
ord-10bcdedee62d4034959f8c27fc37583e
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03960863

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