Allyl bromide → Alimadol

HRID 1657536노트

반응식

HRID 1657536 반응식
[C:1]1([C:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)([O:17][CH3:18])[CH2:8][CH2:9][NH:10][C:11](=O)[C:12](F)(F)F)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:25](Br)C=C.[OH-].[K+]>CC(C)=O>[C:1]1([C:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)([O:17][CH3:18])[CH2:8][CH2:9][NH:10][CH2:11][CH:12]=[CH2:25])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 14797Potassium HydroxideHCID 21534186HCID 21534186, 화합물

생성물 1

HCID 176882Alimadol수율 93%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

16.7 g. of N-(3,3-diphenyl-3-methoxypropyl)-trifluoroacetamide, prepared according to Example 4, and 24.2 g. of allyl bromide in 150 ml. of anhydrous acetone are heated to 50°C. and 11.2 g. of powdered potassium hydroxide are added. The mixture is then boiled for 5 minutes and the solvent is distilled off in vacuo. The residue is boiled for one hour with 100 ml. of water and 100 ml. of methanol and is worked up as in Example 4. 13.1 g. of 1,1-diphenyl-1-methoxy-3-allylaminopropane of melting point 45° to 50°C. are obtained, corresponding to a yield of 93% of theory.

후처리

  1. distillationthe solvent is distilled off in vacuo
  2. waitThe residue is boiled for one hour with 100 ml

출처 및 근거

ORD 기록
ord-60efb1f5ec024113a75fdb0fceebe1bb
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03960960

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