Hydrogen Sulfide → HCID 14447407, 화합물

HRID 1657703노트

반응식

HRID 1657703 반응식
[C:1]1([CH:7]([C:9]([O:11][CH:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O[CH:28]=[S:29])C.S>O1CCCC1>[S:29]=[CH:28][NH:8][CH:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[C:9]([O:11][CH:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)=[O:10]

참가 물질

5

반응물 3

HCID 402Hydrogen SulfideHCID 11073343Methanethioic acid, O-ethyl esterHCID 131710294HCID 131710294, 화합물

생성물 1

HCID 14447407HCID 14447407, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 15.9 g. (0.05 mol.) of α-phenylglycine, diphenylmethyl ester, and 9 g. of (0.1 mol.) of ethylthioformate in 50 ml. of tetrahydrofuran is stirred overnight at room temperature. Then a stream of hydrogen sulfide is passed into the solution for 10 minutes, the reaction mixture is permitted to stand overnight, then concentrated and petroleum ether is added to the residue. 16.9 g. of α-[(thioxomethyl)amino]benzeneacetic acid, diphenylmethyl ester, crystallizes. The crude product is recrystallized from methanol, m.p. 129°-130°.

후처리

  1. concentrationconcentrated
  2. additionpetroleum ether is added to the residue
  3. customof α-[(thioxomethyl)amino]benzeneacetic acid, diphenylmethyl ester, crystallizes
  4. customThe crude product is recrystallized from methanol, m.p. 129°-130°

출처 및 근거

ORD 기록
ord-357c0323264d4f3faa38796271d59cae
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03962229

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