1,2-Dimethoxyethane → 2-(1,3-Dioxaindan-5-yl)acetaldehyde

HRID 1657876노트

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HRID 1657876 반응식
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH2:10][CH:11](S(C)=O)SC)=[CH:4][C:3]=2[O:2]1.C[O:18]CCOC>>[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH2:10][CH:11]=[O:18])=[CH:4][C:3]=2[O:2]1

참가 물질

3

반응물 2

HCID 80711,2-DimethoxyethaneHCID 21530764Methyl 2-(3,4-methylenedioxyphenyl)-1-methylthioethyl sulfoxide

생성물 1

HCID 2678892-(1,3-Dioxaindan-5-yl)acetaldehyde수율 45%

실험 절차

2.08 g of methyl 2-(3,4-methylenedioxyphenyl)-1-methylthioethyl sulfoxide was dissolved in 20 ml. of 1,2-dimethoxyethane, and with the addition of 1.71 g of cupric chloride dihydrate, the solution was refluxed for 15 minutes. The solvent was removed by evaporation at reduced pressure, and 50 ml. of methylene chloride was added. The insoluble water was removed by filtration. The filtrate was concentrated at reduced pressure, and subjected to column chromatography (silica gel, benzene) to give 722 mg of (3,4-methylenedioxyphenyl)acetaldehyde in a yield of 45%.

후처리

  1. temperaturethe solution was refluxed for 15 minutes
  2. customThe solvent was removed by evaporation at reduced pressure, and 50 ml
  3. additionof methylene chloride was added
  4. customThe insoluble water was removed by filtration
  5. concentrationThe filtrate was concentrated at reduced pressure

출처 및 근거

ORD 기록
ord-b7b5e5141b8d453eb6f6e2b2edcdfd64
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03962281

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