Lithium → 2-Nonenal

HRID 1657942노트

반응식

HRID 1657942 반응식
[C:1](Cl)(=[O:10])/[CH:2]=[CH:3]/[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[Li]>COCCOCCOC>[CH:1](=[O:10])/[CH:2]=[CH:3]/[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

참가 물질

4

반응물 2

HCID 3028194LithiumHCID 12575251HCID 12575251, 화합물

생성물 1

HCID 52833352-Nonenal

시약·촉매·용매 1

HCID 8150Diglyme용매2회

반응 조건

온도
-78 °C

실험 절차

Trans-2-nonenoyl chloride (170 g, 1 mole) is dissolved in 500 ml of diglyme and placed in a flask fitted with a mechanical stirrer, dripping funnel, low temperature thermometer and nitrogen inlet and outlet. The flask is flushed with nitrogen and cooled to -78°C in a dry ice acetone bath. To the flask, lithium tri-t-butoxyaluminohydried (254 g, 1 mole) in 1000 ml of diglyme is added over a period of 7 hours. The cooling bath is removed and the contents of the flask are allowed to warm to room temperature. The contents are poured onto crushed ice and the oily layer taken up in ether. The ether solution is dried over sodium sulfate, concentrated and vacuum distilled to give trans-2-nonenal.

후처리

  1. customplaced in a flask
  2. customfitted with a mechanical stirrer
  3. customThe flask is flushed with nitrogen
  4. customThe cooling bath is removed
  5. temperatureto warm to room temperature
  6. additionThe contents are poured
  7. customonto crushed ice
  8. dry with materialThe ether solution is dried over sodium sulfate
  9. concentrationconcentrated
  10. distillationvacuum distilled

출처 및 근거

ORD 기록
ord-444a83e2455c49cbb22f985f85b6fe9b
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03962321

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