(E)-2-Nonenoic Acid → 2-Nonen-1-ol, (2E)-

HRID 1657944노트

반응식

HRID 1657944 반응식
[H-].[H-].[H-].[H-].[Li+].[Al+3].[C:7](O)(=[O:16])/[CH:8]=[CH:9]/[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]>CCOCC>[CH2:7]([OH:16])/[CH:8]=[CH:9]/[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

참가 물질

4

반응물 2

HCID 5312586(E)-2-Nonenoic AcidHCID 21226445Aluminium lithium hydride

생성물 1

HCID 53649412-Nonen-1-ol, (2E)-

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A 500 ml flask with a reflux condenser, mechanical stirrer and a dropping funnel, and protected from moisture with a drying tube is charged with LiAlH4 (6.1 g, 0.16 mole) and 200 ml ether. A solution of trans-2-nonenoic acid (7.8 g, 0.05 mole) in 25 ml ether is added at a rate to maintain refluxing. Refluxing is continued for 1 hour and the mixture cooled. Exess reagent is destroyed by the addition of ethyl acetate (5 ml) followed by acidification with 5M HCl. The organic layer is separated, washed with water, dried and distilled under vacuum to give trans-2-nonenol.

후처리

  1. customA 500 ml flask with a reflux condenser, mechanical stirrer and a dropping funnel, and protected from moisture with a drying tube
  2. temperatureto maintain
  3. temperaturerefluxing
  4. temperatureRefluxing
  5. temperaturethe mixture cooled
  6. customExess reagent is destroyed by the addition of ethyl acetate (5 ml)
  7. customThe organic layer is separated
  8. washwashed with water
  9. customdried
  10. distillationdistilled under vacuum

출처 및 근거

ORD 기록
ord-885c5416208049a48577fb256c5ab3b5
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03962321

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