Triethylamine → HCID 21532249, 화합물

HRID 1657959

반응식

HRID 1657959 반응식
[F:1][C:2]([CH:5]([C:9]([F:11])=[O:10])[C:6]([F:8])=[O:7])([F:4])[F:3].C(N(CC)CC)C.Cl[CH2:20][CH:21]=[C:22]([CH3:24])[CH3:23]>CCOCC>[CH3:23][C:22]([CH3:24])=[CH:21][CH2:20][C:5]([C:2]([F:4])([F:3])[F:1])([C:6]([F:8])=[O:7])[C:9]([F:11])=[O:10]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 104291-Chloro-3-methyl-2-buteneHCID 12951306Trifluoromethylmalonyl fluoride

생성물 1

HCID 21532249HCID 21532249, 화합물수율 16%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

반응 조건

온도
25 °C

실험 절차

To 17.6 g (0.10 mol) of trifluoromethylmalonyl fluoride and 50 ml of ether stirred at -80°C was added dropwise a solution of 9.2 g (0.09 mol) of triethylamine in 25 ml of ether. Then 12.5 g (0.12 mol) of 1-chloro-3-methyl-2-butene was added, and the mixture was stirred at 25°C until homogeneous. After standing at 25°C for 3 days, the mixture was distilled to give 3.9 g (16%) of (3-methyl-2-butenyl)-trifluoromethylmalonyl fluoride, bp 43°-45°C (20 mm); ir (CCl4): 3.31, 3.37 and 3.42 (CH), 5.36 (C=O) and 7.5-8.5 μ (CF).

후처리

  1. distillationthe mixture was distilled

출처 및 근거

ORD 기록
ord-dc7b92157e634e0387fa3652a95c5efb
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03962325

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