Sulfuric Acid → Diethyl (2-hydroxyethyl)phosphonate

HRID 1657986노트

반응식

HRID 1657986 반응식
[CH2:1]([O:3][P:4]([CH2:9][CH2:10][O:11]C(=O)C)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].OS(O)(=O)=O>C(O)C>[CH2:6]([O:5][P:4]([CH2:9][CH2:10][OH:11])(=[O:8])[O:3][CH2:1][CH3:2])[CH3:7]

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 124696282-(Diethoxyphosphoryl)ethyl acetate

생성물 1

HCID 312225Diethyl (2-hydroxyethyl)phosphonate수율 80%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

100 g of 2-acetoxyethane phosphonic acid diethyl ester are heated to 80°C jointly with 200 ml of ethanol. To this solution are added dropwise within 5 hours 20 ml of ethanol containing 1 wt.% of H2SO4 while simultaneously removing by continuous distillation a mixture of ethylacetate and ethanol. The residue is submitted to distillation under reduced pressure. 64 g of 2-hydroxyethane-phosphonic acid diethyl ester are obtained, corresponding to a yield of 80% of the theoretical.

후처리

  1. customwhile simultaneously removing by continuous distillation
  2. additiona mixture of ethylacetate and ethanol
  3. distillationThe residue is submitted to distillation under reduced pressure

출처 및 근거

ORD 기록
ord-693111acb26648e3a0c340ae159facb7
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03962378

반응 노트

불러오는 중…