Thionyl Chloride → 2-Azido-2-methoxyacetyl chloride

HRID 1658005노트

반응식

HRID 1658005 반응식
[N:1]([CH:4]([O:8][CH3:9])[C:5](O)=[O:6])=[N+:2]=[N-:3].S(Cl)([Cl:12])=O>>[N:1]([CH:4]([O:8][CH3:9])[C:5]([Cl:12])=[O:6])=[N+:2]=[N-:3]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 215299592-Azido-2-methoxyacetic acid

생성물 1

HCID 215299292-Azido-2-methoxyacetyl chloride

반응 조건

온도
80 °C

실험 절차

A solution of 2-azido-2-methoxyacetic acid (4.2 g.) in thionyl chloride (10 ml.) is heated in an oil bath maintained at 80°C. for 20 minutes. After cooling to room temperature, the mixture is evaporated in vacuo to remove excess thionyl chloride and the residue is distilled to yield 2-azido-2-methoxyacetyl chloride (2.26 g.) as a water-white liquid (b.p. 64°-66°C./27 mm.).

후처리

  1. temperatureAfter cooling to room temperature
  2. customthe mixture is evaporated in vacuo
  3. customto remove excess thionyl chloride
  4. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-10fdb16b88914a318645158beba07bf6
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03962224

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