(3-Amino-4-hydroxyphenyl)acetic acid → 5-Benzoxazoleacetic acid, 2-(4-chlorophenyl)-

HRID 1658086노트

반응식

HRID 1658086 반응식
CCO[CH2:4][CH3:5].[ClH:6].[NH2:7][C:8]1[CH:9]=[C:10]([CH2:15][C:16]([OH:18])=[O:17])[CH:11]=[CH:12][C:13]=1[OH:14]>CO>[Cl:6][C:8]1[CH:9]=[CH:10][C:4]([C:5]2[O:14][C:13]3[CH:12]=[CH:11][C:10]([CH2:15][C:16]([OH:18])=[O:17])=[CH:9][C:8]=3[N:7]=2)=[CH:12][CH:13]=1

참가 물질

4

반응물 2

HCID 1473103(3-Amino-4-hydroxyphenyl)acetic acidHCID 10953452Ether hydrochloride

생성물 1

HCID 30397785-Benzoxazoleacetic acid, 2-(4-chlorophenyl)-

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A suspension of p-chlorobenzimidoethyl ether hydrochloride (16.5 g.) and 3-amino- 4-hydroxyphenylacetic acid (12.53 g.) in methanol (75 ml.) was refluxed for 2 hours. After standing at room temperature overnight the white solid product was removed by filtration. Re-crystallisation from ethanol gave the required acid, m.p. 241°- 242°C.

후처리

  1. temperaturewas refluxed for 2 hours
  2. customthe white solid product was removed by filtration

출처 및 근거

ORD 기록
ord-42c38933b88a4aa89f5001dcf22d39fb
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03962441

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