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[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH2:3][CH2:2]1.C=O.[C:18](=[O:21])([O-])[O-].[K+].[K+].[CH2:24](O)[CH3:25]>>[CH2:24]([O:21][CH2:18][N:1]1[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9](=[O:15])[O:10][C:11]([CH3:12])([CH3:14])[CH3:13])[CH2:3][CH2:2]1)[CH3:25]참가 물질
5
실험 절차
To a stirred solution of tert-butyl (piperidin-4-ylmethyl)carbamate (7.0 g, 33 mmol) in ethanol (19 mL), paraformaldehyde (1.2 g, 39 mmol) and potassium carbonate (5.4 g, 39 mmol) were added at ambient temperature. The mixture was stirred at ambient temperature for 4 h. The mixture was filtered and the filter cake was washed with ethanol (50 mL). The volatile components were removed by evaporation to give the title compound 8.9 g (quant.) as a white powder.
후처리
- filtrationThe mixture was filtered
- washthe filter cake was washed with ethanol (50 mL)
- customThe volatile components were removed by evaporation
출처 및 근거
- ORD 기록
- ord-ea6c31155be54dbcb207cf0d781a0ce8
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07737163B2
연결된 노트
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