Chloroacetyl chloride → 2-Chloro-N-(2-bromo-4-sulphamoylphenyl)-acetamide

HRID 1658206노트

반응식

HRID 1658206 반응식
[Br:1][C:2]1[CH:8]=[C:7]([S:9](=[O:12])(=[O:11])[NH2:10])[CH:6]=[CH:5][C:3]=1[NH2:4].[Cl:13][CH2:14][C:15](Cl)=[O:16]>>[Cl:13][CH2:14][C:15]([NH:4][C:3]1[CH:5]=[CH:6][C:7]([S:9](=[O:12])(=[O:11])[NH2:10])=[CH:8][C:2]=1[Br:1])=[O:16]

참가 물질

3

반응물 2

HCID 6577Chloroacetyl chlorideHCID 35265234-Amino-3-bromobenzene-1-sulfonamide

생성물 1

HCID 215288442-Chloro-N-(2-bromo-4-sulphamoylphenyl)-acetamide수율 78.6%

실험 절차

2-Bromo-4-sulphamoylaniline (20.0 g) and α-chloroacetyl chloride (25.0 g) were refluxed together for 60 min. and the product worked up as in Example 2(a) to yield 20.5 g white needles, m.p. 174°-175°

출처 및 근거

ORD 기록
ord-847c5c86a5144bee89a84ec87d91ff31
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03963706

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