NaNCO → N-(2,3-Dihydro-1-benzofuran-5-yl)-N-propan-2-ylurea

HRID 1658283노트

반응식

HRID 1658283 반응식
[CH:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]2[O:12][CH2:11][CH2:10][C:9]=2[CH:13]=1)([CH3:3])[CH3:2].[N-:14]=[C:15]=[O:16].[Na+]>C(O)(=O)C>[CH:1]([N:4]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][CH2:11][CH2:10][C:9]=2[CH:13]=1)[C:15]([NH2:14])=[O:16])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 11051568NaNCOHCID 21529005N-isopropyl-2,3-dihydro-5-benzofuranamine

생성물 1

HCID 21529015N-(2,3-Dihydro-1-benzofuran-5-yl)-N-propan-2-ylurea

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 14.2 g. of N-isopropyl-2,3-dihydro-5-benzofuranamine in 300 ml. of glacial acetic acid, cooled to 15°±5°C. is added 4.9 g. of sodium isocyanate. The mixture is stirred at room temperature for 18 hours and then concentrated in vacuo. The residue is treated with 200 ml. of 2N sodium hydroxide solution and then extracted twice with chloroform. The combined chloroform extracts are dried with anhydrous magnesium fulfate, filtered and concentrated in vacuo to obtain an oil of 1-isopropyl-1-(2,3-dihydro-5-benzofuranyl)urea.

후처리

  1. additionis added 4.9 g
  2. concentrationconcentrated in vacuo
  3. additionThe residue is treated with 200 ml
  4. extractionof 2N sodium hydroxide solution and then extracted twice with chloroform
  5. dry with materialThe combined chloroform extracts are dried with anhydrous magnesium fulfate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-fbe4d884e36d4e7abed926bfcffcb84c
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03963717

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