Methanol → N-isopropyl-2,3-dihydro-6-benzofuranamine

HRID 1658285노트

반응식

HRID 1658285 반응식
[O:1]1[C:5]2[CH:6]=[C:7]([NH2:10])[CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1.CO.[CH:13](I)([CH3:15])[CH3:14]>C(N(CC)CC)C>[CH:13]([NH:10][C:7]1[CH:8]=[CH:9][C:4]2[CH2:3][CH2:2][O:1][C:5]=2[CH:6]=1)([CH3:15])[CH3:14]

참가 물질

5

반응물 3

HCID 887MethanolHCID 6362Isopropyl iodideHCID 123690442,3-Dihydro-1-benzofuran-6-amine

생성물 1

HCID 21528943N-isopropyl-2,3-dihydro-6-benzofuranamine

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

To a solution of 2.8 g. of 2,3-dihydro-6-benzofuranamine in 150 ml. of methanol is added 18 ml. of isopropyl iodide and 26.5 ml. of triethylamine. The solution is refluxed for 60 hours and then concentrated in vacuo. The resultant oil is extracted repeatedly with diethyl ether. The extracts are combined, filtered through Celite, and the ether removed in vacuo to give an oil of N-isopropyl-2,3-dihydro-6-benzofuranamine.

후처리

  1. temperatureThe solution is refluxed for 60 hours
  2. concentrationconcentrated in vacuo
  3. extractionThe resultant oil is extracted repeatedly with diethyl ether
  4. filtrationfiltered through Celite
  5. customthe ether removed in vacuo

출처 및 근거

ORD 기록
ord-a51d9ac27980474b8dd4ba0d8f526425
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03963717

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