Methanol → N-isopropyl-2,3-dihydro-7-benzofuranamine

HRID 1658289노트

반응식

HRID 1658289 반응식
[O:1]1[C:5]2[C:6]([NH2:10])=[CH:7][CH:8]=[CH:9][C:4]=2[CH2:3][CH2:2]1.CO.[CH:13](I)([CH3:15])[CH3:14]>C(N(CC)CC)C>[CH:13]([NH:10][C:6]1[C:5]2[O:1][CH2:2][CH2:3][C:4]=2[CH:9]=[CH:8][CH:7]=1)([CH3:15])[CH3:14]

참가 물질

5

반응물 3

HCID 887MethanolHCID 6362Isopropyl iodideHCID 128059502,3-Dihydro-1-benzofuran-7-amine

생성물 1

HCID 21528960N-isopropyl-2,3-dihydro-7-benzofuranamine

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

To a solution of 15 g. of 2,3-dihydro-7-benzofuranamine in 150 ml. of methanol is added 8.5 ml. of isopropyl iodide and 13.4 ml. of triethylamine. The solution is refluxed for 45 hours and then concentrated in vacuo. The resulting oil is extracted several times with diethyl ether, the ether extracted combined filtered through Celite, and the ether removed in vacuo to obtain an oil of N-isopropyl-2,3-dihydro-7-benzofuranamine.

후처리

  1. temperatureThe solution is refluxed for 45 hours
  2. concentrationconcentrated in vacuo
  3. extractionThe resulting oil is extracted several times with diethyl ether
  4. extractionthe ether extracted
  5. filtrationcombined filtered through Celite
  6. customthe ether removed in vacuo

출처 및 근거

ORD 기록
ord-a1faca4a36954c76af9ae6b1b10ea945
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03963717

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