Aniline → 4-Chloro-N-phenylphthalimide

HRID 1658539

반응식

HRID 1658539 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:8][C:9]1[CH:10]=[C:11]([C:18](O)=[O:19])[C:12](=[CH:16][CH:17]=1)[C:13](O)=[O:14]>C1(C)C(C)=CC=CC=1>[Cl:8][C:9]1[CH:10]=[C:11]2[C:18](=[O:19])[N:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:13](=[O:14])[C:12]2=[CH:16][CH:17]=1

참가 물질

4

반응물 2

HCID 6115AnilineHCID 69644-Chlorophthalic acid

생성물 1

HCID 111187184-Chloro-N-phenylphthalimide

시약·촉매·용매 1

HCID 7237O-Xylene용매2회

반응 조건

온도
5 °C

실험 절차

To a suspension of 750 g of monosodium-4-chlorophthalate and 1200 ml water was added 120 ml conc. sulfuric acid. The resulting brown solution was extracted with three 400 ml portions of ether. The combined extracts were treated with carbon black, filtered and the ether distilled. The 4-chlorophthalic acid obtained was dehydrated by heating to 170°C for two hours to give 548 g of anhydride. To a solution of the anhydride in 2250 ml of xylene was added 279 g of aniline diluted with an equal weight of xylene. The solution was refluxed for 16 hours and the water formed was collected in a Dean-Stark trap. After treatment with carbon black the hot xylene solution was cooled to 5°C to give 475 g of crude 4-chloro-N-phenyl phthalimide. Recrystallization from 2000 ml toluene, twice, provided 364 g of 92% pure imide.

후처리

  1. temperatureThe solution was refluxed for 16 hours
  2. customwas collected in a Dean-Stark trap

출처 및 근거

ORD 기록
ord-593554fdb6644ea391bc3dc7677326f4
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03965125

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