Potassium Iodide → 1-Butanone, 1-(4-fluorophenyl)-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-, hydrochloride

HRID 1658658노트

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HRID 1658658 반응식
[C:1]1([C:7]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[OH:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:21][CH2:22][CH2:23][CH2:24][C:25]([C:27]1[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=1)=[O:26].[I-].[K+].C(=O)(O)[O-].[Na+]>C1(C)C=CC=CC=1>[ClH:21].[F:33][C:30]1[CH:29]=[CH:28][C:27]([C:25](=[O:26])[CH2:24][CH2:23][CH2:22][N:12]2[CH2:13][CH2:14][CH:9]([C:7]([OH:8])([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH2:10][CH2:11]2)=[CH:32][CH:31]=1

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 15723AzacyclonolHCID 197503-(4-Fluorobenzoyl)propyl chlorideHCID 516892Sodium Bicarbonate

생성물 1

HCID 2061821-Butanone, 1-(4-fluorophenyl)-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)-, hydrochloride

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 26.73 g (0.1 mole) of α,α -diphenyl-4-piperidinemethanol, 22 g (0.11 mole) of 4-chloro-4' -fluorobutyrophenone, a trace of potassium iodide and 13.5 g (0.16 mole) of sodium bicarbonate in 500 ml of toluene was refluxed for 21/2 days. The mixture was filtered, and the filtrate was cooled. The resulting solid was converted by generally known methods to the hydrochloride salt which was recrystallized from methanol and butanone to give the desired product, M.P. 224.5°-225.5° C.

후처리

  1. filtrationThe mixture was filtered
  2. temperaturethe filtrate was cooled
  3. customwas recrystallized from methanol and butanone

출처 및 근거

ORD 기록
ord-f908f56bbab342eea966ce478e33b3bd
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03965257

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