Pyridine → 2-(2-Fluoroacetamido)-N-(2-methylphenyl)-5-nitrobenzamide

HRID 1658722노트

반응식

HRID 1658722 반응식
[NH2:1][C:2]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:3]=1[C:4]([NH:6][C:7]1[C:8]([CH3:13])=[CH:9][CH:10]=[CH:11][CH:12]=1)=[O:5].N1C=CC=CC=1.[F:27][CH2:28][C:29](Cl)=[O:30]>O1CCCC1>[F:27][CH2:28][C:29]([NH:1][C:2]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:3]=1[C:4]([NH:6][C:7]1[C:8]([CH3:13])=[CH:9][CH:10]=[CH:11][CH:12]=1)=[O:5])=[O:30]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 9663Fluoroacetyl chlorideHCID 124873692-Amino-N-(2-methylphenyl)-5-nitrobenzamide

생성물 1

HCID 215254582-(2-Fluoroacetamido)-N-(2-methylphenyl)-5-nitrobenzamide수율 93.7%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

14.4 g(0.053 mol) of N-(2-amino-5-nitrobenzoyl)-o-toluidine and 6.3 g(0.08 mol) of pyridine are dissolved in 300 ml of tetrahydrofuran. 12.2 g(0.126 mol) of fluoroacetyl chloride are added to the solution for 10 minutes under ice-cooling. The solution is stirred at the same temperature for 30 minutes and then at room temperature for 2.5 hours. The reaction solution is allowed to stand at room temperature overnight. The crystalline precipitate is collected by filtration, washed with water and then dried. 16.4 g of N-(2-fluoroacetamido-5-nitrobenzoyl)-o-toluidine are obtained.

후처리

  1. temperaturecooling
  2. waitat room temperature for 2.5 hours
  3. waitto stand at room temperature overnight
  4. filtrationThe crystalline precipitate is collected by filtration
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-8f1f19b74be44caa9ca7c68e4adaf40e
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03966731

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