Selenium Dioxide → HCID 178469709, 화합물
반응식
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[C:8]2[CH:14]=[N:13][N:12](CC3C=CN=CC=3)[C:9]2=[N:10][CH:11]=1)=[O:5])[CH3:2].[Se](=O)=[O:23]>C(O)(=O)C.O>[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:23])=[C:8]2[CH:14]=[N:13][NH:12][C:9]2=[N:10][CH:11]=1)=[O:5])[CH3:2]참가 물질
5
실험 절차
3 g of 4-hydroxy-1-(4-picolyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester (0.01 mol) is dissolved in 20 ml of acetic acid. 2.2 g of selenium dioxide (0.02 mol) and 2-3 drops of water are added. The mixture is refluxed for 30 minutes and then filtered off. 4-Hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester precipitates on cooling. Recrystallization from acetic acid yields 1.8 g (87%), m.p. 275°.
후처리
- temperatureThe mixture is refluxed for 30 minutes
- filtrationfiltered off
- custom4-Hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester precipitates
- temperatureon cooling
- customRecrystallization from acetic acid
- customyields 1.8 g (87%), m.p. 275°
출처 및 근거
- ORD 기록
- ord-1be135eccc06414f836f90eccde4a3ec
- 출처 데이터셋
- uspto-grants-1976_06
- 특허 번호
- US03966746
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