HCID 21505599, 화합물 → HCID 21525672, 화합물

HRID 1658807노트

반응식

HRID 1658807 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:23])[CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH:16]=[C:15]([C:18]3[O:19][CH:20]=[CH:21][N:22]=3)[CH2:14][CH2:13]2)=[CH:4][CH:3]=1>[Pd].C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:23])[CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[O:19][CH:20]=[CH:21][N:22]=3)[CH2:14][CH2:13]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 21505599HCID 21505599, 화합물

생성물 1

HCID 21525672HCID 21525672, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A 0.32 g. portion of 3,6-dihydro-α-(p-fluorophenyl)-4-(2-oxazolyl)-1(2H)-pyridinebutanol, prepared as described in Example 15, is dissolved in 10 ml. of ethanol and 0.1 g. of palladium on carbon catalyst is added. The mixture is reduced at room temperature and pressure for 4 hours and then filtered. The filtrate is evaporated giving an oil which solidifies to a white solid. This solid is recrystallized twice from acetonitrile, m.p. 99°-100°C.

후처리

  1. dissolutionis dissolved in 10 ml
  2. customis reduced at room temperature
  3. filtrationfiltered
  4. customThe filtrate is evaporated
  5. customgiving an oil which
  6. customThis solid is recrystallized twice from acetonitrile, m.p. 99°-100°C.

출처 및 근거

ORD 기록
ord-de1a2b649bd7474c912c0e76e4af0c36
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03966748

반응 노트

불러오는 중…