Sulfuric Acid → 1-Chloro-4-[2,2,2-trichloro-1-(4-chlorophenoxy)ethyl]benzene

HRID 1658978노트

반응식

HRID 1658978 반응식
[Cl:1][C:2]([Cl:13])([Cl:12])[CH:3]([OH:11])[C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][CH:5]=1.[Cl:14][C:15]1[CH:20]=[CH:19][C:18](O)=[CH:17][CH:16]=1.S(=O)(=O)(O)O>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([O:11][CH:3]([C:2]([Cl:1])([Cl:12])[Cl:13])[C:4]2[CH:5]=[CH:6][C:7]([Cl:10])=[CH:8][CH:9]=2)=[CH:17][CH:16]=1

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 46844-ChlorophenolHCID 214174-Chloro-alpha-(trichloromethyl)benzenemethanol

생성물 1

HCID 215268891-Chloro-4-[2,2,2-trichloro-1-(4-chlorophenoxy)ethyl]benzene

실험 절차

α-trichloromethyl-p-chlorobenzyl alcohol, 5.0g, was stirred with p-chlorophenol, 2.6g, and sulfuric acid, 35 ml, was added dropwise. After 2 hrs. of stirring, the mixture was poured onto ice and extracted with ether. After drying with sodium sulfate, the ether was removed under vacuum and the residue was recrystallized from ethanol to give α-trichloromethyl-p-chlorobenzyl p-chlorophenyl ether, mp 101°C. This method of synthesis is referred to in Table I as method A.

후처리

  1. additionwas added dropwise
  2. additionthe mixture was poured onto ice
  3. extractionextracted with ether
  4. dry with materialAfter drying with sodium sulfate
  5. customthe ether was removed under vacuum
  6. customthe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-606723cb101542fcac09f8013b72e1f1
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03966824

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