참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diethylamine | HCID 8021 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | HCID 178418412 | HCID 178418412 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178418381 | HCID 178418381 | — |
반응 단계
A solution of 1 g (3.75 mmol) of trans-O-acetyl-4-(4-chloromethylphenyl)-cyclohexanol in 10 ml of dimethylformamide is mixed with 0.52 g (3.75 mmol) of potassium carbonate and 0.27 g (3.75 mmol) of diethylamine. This mixture is heated to 50° C. for 6 hours with stirring, then water is added and the mixture is extracted with methylene chloride. The organic phase is dried, evaporated down in vacuo and the residue remaining is purified by column chromatography (aluminium oxide basic, activity stage III, ICN; petroleum ether/ethyl acetate=15:1). Colourless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05726205 |
|---|
| 출처 데이터셋 | uspto-grants-1998_03 |
|---|
| ORD ID | ord-d5a8195f23794884af3a23a8c8f6148d |
|---|
| 출처 메모 | uspto-grants-1998_03 |
|---|
