1-(1-Piperidinylcarbonyl)piperazine → 1-(4-Piperidinocarbonyl-1-piperazinyl)-6,7-diethoxyisoquinoline

HRID 1659096노트

반응식

HRID 1659096 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:15][CH2:16][CH3:17])=[C:9]([O:12][CH2:13][CH3:14])[CH:10]=2)[CH:5]=[CH:4][N:3]=1.[N:18]1([C:24]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[O:25])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1>>[N:18]1([C:24]([N:26]2[CH2:27][CH2:28][N:29]([C:2]3[C:11]4[C:6](=[CH:7][C:8]([O:15][CH2:16][CH3:17])=[C:9]([O:12][CH2:13][CH3:14])[CH:10]=4)[CH:5]=[CH:4][N:3]=3)[CH2:30][CH2:31]2)=[O:25])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1

참가 물질

3

반응물 2

HCID 10950151-(1-Piperidinylcarbonyl)piperazineHCID 215271091-Chloro-6,7-diethoxyisoquinoline

생성물 1

HCID 215271191-(4-Piperidinocarbonyl-1-piperazinyl)-6,7-diethoxyisoquinoline

실험 절차

In like manner, 1-chloro-6,7-diethoxyisoquinoline and 1-(piperidinocarbonyl)piperazine react to afford 1-(4-piperidinocarbonyl-1-piperazinyl)-6,7-diethoxyisoquinoline, while 4-chloro-6,7-dimethoxyquinazoline and 1-(piperidinocarbonyl)piperazine react to afford 4-(4-piperidinocarbonyl-1-piperazinyl)-6,7-dimethoxyquinazoline respectively. The latter compound is, of course, identical in every respect with the product of Example V.

출처 및 근거

ORD 기록
ord-b2a27f62831f4b859ad63d7e5e544e59
출처 데이터셋
uspto-grants-1976_06
특허 번호
US03966936

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