1-Nitro-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline → 1-Amino-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline

HRID 1659350노트

반응식

HRID 1659350 반응식
[N+:1]([C:4]1[CH:5]=[N:6][N:7]2[C:16]=1[C:15]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:9]([C:17](=[O:19])[CH3:18])[CH:8]2[CH3:20])([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][N:7]2[C:16]=1[C:15]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:9]([C:17](=[O:19])[CH3:18])[CH:8]2[CH3:20]

참가 물질

4

반응물 1

HCID 131756751-Nitro-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline

생성물 1

HCID 131756851-Amino-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline수율 84.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

27.1 g (0.1 mole) of 1-nitro-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline are hydrogenized in ethanol in the presence of palladium/carbon catalyst. When the reduction is complete, the catalyst is removed by filtration and the filtrate is evaporated in an inert atmosphere under reduced pressure. 20.5 g (81%) of 1-amino-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline are obtained as white crystals. M.p.: 170°-172° C.

후처리

  1. customthe catalyst is removed by filtration
  2. customthe filtrate is evaporated in an inert atmosphere under reduced pressure

출처 및 근거

ORD 기록
ord-8fb6098d93244619b7c8d45ab751056c
출처 데이터셋
uspto-grants-1981_12
특허 번호
US04303660

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