Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-[(2-Oxotetrahydro-3-furanyl)sulfanyl]benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-Mercaptobenzoic Acid | HCID 5443 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 2(3H)-Furanone, 3-bromodihydro- | HCID 95463 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-[(2-Oxotetrahydro-3-furanyl)sulfanyl]benzoic acid | HCID 13622276 | 84.1% |
반응 단계
In 250 ml of water are dissolved 25 g of thiosalicylic acid and 60 g of sodium carbonate. Then, under ice-cooling, 38 g of α-bromo-γ-butyrolactone is added dropwise. The mixture is stirred at room temperature for 3 hours. The reaction mixture is made acidic with dilute hydrochloric acid and the resultant precipitate is recovered by filtration, rinsed with water and recrystallized from ethanol. By the above procedure there is obtained 32.5 g of α-[(2-carboxyphenyl)thio]-γ-butyrolactone as colorless prisms melting at 180°-182° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04304784 |
| 출처 데이터셋 | uspto-grants-1981_12 |
| ORD ID | ord-7de1dec7d360495e8718f7b62c4fa06e |
| 출처 메모 | uspto-grants-1981_12 |