1,4-Dihydro-2,6-dimethyl-4-(2-(trifluoromethyl)phenyl)-3,5-pyridinedicarboxylic acid diethyl ester → Ethyl 1,4,5,6-Tetrahydro-2-methyl-4-(2-trifluoromethylphenyl)-5-oxo-6,7-diphenyl-1,6-naphthyridine-3-carboxylate

HRID 1659609

반응식

HRID 1659609 반응식
[F:1][C:2]([F:28])([F:27])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[C:14]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[C:13]([CH3:20])[NH:12][C:11]([CH3:21])=[C:10]1[C:22]([O:24]CC)=O.[C:29]1([N:35]=[C:36](Cl)[C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[CH3:20][C:13]1[NH:12][C:11]2[CH:21]=[C:36]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[N:35]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:22](=[O:24])[C:10]=2[CH:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[C:2]([F:27])([F:28])[F:1])[C:14]=1[C:15]([O:17][CH2:18][CH3:19])=[O:16]

참가 물질

3

반응물 2

HCID 1680891,4-Dihydro-2,6-dimethyl-4-(2-(trifluoromethyl)phenyl)-3,5-pyridinedicarboxylic acid diethyl esterHCID 264587N-Phenylbenzimidoyl chloride

생성물 1

HCID 20559737Ethyl 1,4,5,6-Tetrahydro-2-methyl-4-(2-trifluoromethylphenyl)-5-oxo-6,7-diphenyl-1,6-naphthyridine-3-carboxylate

실험 절차

This product is obtained using the procedure of Example 1 from diethyl 1,4-dihydro-4-(2-trifluoromethylphenyl)-2,6-dimethyl-3,5-pyridine dicarboxylate and N-phenylbenzimidoyl chloride (1.8 g, 68%).

후처리

  1. customThis product is obtained

출처 및 근거

ORD 기록
ord-d48ddfb23e16472081aaef03bd7f5a03
출처 데이터셋
uspto-grants-1981_12
특허 번호
US04304914

연결된 노트

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