4-Chloro-2-phenylquinazoline → 4-[3-(2-Methoxyphenoxy)-1-pyrrolidinyl]-2-phenylquinazoline

HRID 1659954노트

반응식

HRID 1659954 반응식
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][CH:12]=[CH:11][C:4]=1[O:5][CH:6]1[CH2:10][CH2:9][NH:8][CH2:7]1.Cl[C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:19]=[C:18]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:17]=1>C(O)(C)C>[CH3:1][O:2][C:3]1[CH:14]=[CH:13][CH:12]=[CH:11][C:4]=1[O:5][CH:6]1[CH2:10][CH2:9][N:8]([C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]=[C:18]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[N:17]=2)[CH2:7]1

참가 물질

4

반응물 2

HCID 809774-Chloro-2-phenylquinazolineHCID 144973553-(2-Methoxyphenoxy)pyrrolidine

생성물 1

HCID 127960364-[3-(2-Methoxyphenoxy)-1-pyrrolidinyl]-2-phenylquinazoline

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

To a solution containing 150 ml of isopropanol and 4.8 g (0.025 mole) of 3-o-methoxyphenoxypyrrolidine was added, with stirring, 6.15 g (0.025 mole) of 4-chloro-2-phenylquinazoline. The reaction was exothermic and the mixture refluxed for 15 min. The temperature subsided to room temperature and, after standing at room temperature for 11/2 hr, the resulting reaction mixture was filtered. The crystalline solid was recrystallized with isopropanol. Yield of product was 1.9 g, m.p. 142°-144° C.

후처리

  1. additionwas added
  2. temperaturethe mixture refluxed for 15 min
  3. customsubsided to room temperature
  4. customafter standing at room temperature for 11
  5. custom2 hr
  6. customthe resulting reaction mixture
  7. filtrationwas filtered
  8. customThe crystalline solid was recrystallized with isopropanol

출처 및 근거

ORD 기록
ord-1afd9a9325fb4804a49344e73644e83a
출처 데이터셋
uspto-grants-1981_12
특허 번호
US04306065

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