2-Chloro-4-aminopyrimidine → (3-(2-Chloropyrimidin-4-ylamino)-4-fluorophenyl)methanol

HRID 166

반응식

HRID 166 반응식
Nc1ccnc(Cl)n1.OCc1ccc(F)c(Br)c1>C1COCCO1.CC(=O)O.CC(=O)O.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.O=C([O-])[O-].[Cs+].[Cs+].[Pd]>OCc1ccc(F)c(Nc2ccnc(Cl)n2)c1

참가 물질

7

반응물 2

HCID 3457522-Chloro-4-aminopyrimidineHCID 27733513-Bromo-4-fluorobenzyl Alcohol

생성물 1

HCID 59817845(3-(2-Chloropyrimidin-4-ylamino)-4-fluorophenyl)methanol수율 0%

시약·촉매·용매 4

HCID 10796Cesium carbonate시약HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)촉매HCID 4144353Palladium (II) acetate촉매HCID 312751,4-Dioxane용매

반응 조건

온도
150 °C

실험 절차

diacetoxypalladium (8.67 mg, 0.04 mmol) was added to 2-chloropyrimidin-4-amine (100 mg, 0.77 mmol), (3-bromo-4-fluorophenyl)methanol (158 mg, 0.77 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (53.6 mg, 0.09 mmol) and cesium carbonate (503 mg, 1.54 mmol) in 1,4-dioxane (4 mL) . The resulting suspension was stirred at 150 °C in the microwave for 30 minutes. None of the desired material was visible by LCMS. Reaction abandoned.

출처 및 근거

ORD 기록
ord-99e222e4d9a34b6bb8073fb91a88f0f7
출처 데이터셋
750 AstraZeneca ELN dataset
원본 링크
출처 보기

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