Diethyl Ether → Acetophenone
반응식
[CH:1]1([CH2:7][CH:8]2CCCCN2CC(C2C=CC=C(Br)C=2)C)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([Li])CCC.C([O:31]CC)C>>[C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)(=[O:31])[CH3:8]참가 물질
4
실험 절차
Following a procedure similar to that described in Example 3, 37.8 g. (0.1 mole) of 2-cyclohexylmethyl-1-[2-(3-bromophenyl)propyl]piperidine was reacted with 0.18 mole of n-butyl lithium in diethyl ether and the resulting lithio derivative reacted directly with 27 g. (0.23 mole) of acetophenone to give 11.8 g. of 2-cyclohexylmethyl-1-{2-[3-(α-hydroxy-α-methylbenzyl)phenyl]propyl}piperidine as a yellow oil.
출처 및 근거
- ORD 기록
- ord-c2bd75ad813b4df9aa36081e787bd601
- 출처 데이터셋
- uspto-grants-1981_12
- 특허 번호
- US04308382
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