HCID 67021301, 화합물 → HCID 60925354, 화합물

HRID 1660953노트

반응식

HRID 1660953 반응식
[CH3:1][N:2]([CH:16]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]1)[C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][C:4]=1[C:12]([F:15])([F:14])[F:13]>CCO.[Pd]>[CH3:1][N:2]([CH:16]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18][CH2:17]1)[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][C:4]=1[C:12]([F:15])([F:13])[F:14]

참가 물질

4

반응물 1

HCID 67021301HCID 67021301, 화합물

생성물 1

HCID 60925354HCID 60925354, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A suspension of methyl-(1-methyl-piperidin-4-yl)-(4-nitro-2-trifluoromethyl-phenyl)amine (0.812 g, 2.56 mmol) and Pd/C (10%) (0.200 g) in EtOH (20 mL) is stirred for 1 h 25 min at rt, under a hydrogen atmosphere. The reaction mixture is filtered through a pad of Celite and concentrated to afford the title compound as a yellow oil: ES-MS: 288.1 [M+H]+; single peak at tR=1.50 min (System 1).

후처리

  1. filtrationThe reaction mixture is filtered through a pad of Celite
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4b1c413bac394ba096db4a93022392d3
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030311B2

반응 노트

불러오는 중…