HCID 63695501, 화합물 → 2-(2-Chloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-N-{4-[(3-dimethylamino-propyl)-methyl-amino]-3-trifluoromethyl-phenyl}-acetamide
반응식
[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[N:10]=[CH:9]2)[CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([OH:20])=O.[CH3:21][N:22]([CH3:39])[CH2:23][CH2:24][CH2:25][N:26]([CH3:38])[C:27]1[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][C:28]=1[C:34]([F:37])([F:36])[F:35]>C(Cl)Cl.CO>[Cl:1][C:2]1[CH:7]=[C:6]([N:8]2[C:12]3=[N:13][CH:14]=[CH:15][CH:16]=[C:11]3[N:10]=[CH:9]2)[CH:5]=[CH:4][C:3]=1[CH2:17][C:18]([NH:33][C:30]1[CH:31]=[CH:32][C:27]([N:26]([CH2:25][CH2:24][CH2:23][N:22]([CH3:21])[CH3:39])[CH3:38])=[C:28]([C:34]([F:35])([F:36])[F:37])[CH:29]=1)=[O:20]참가 물질
4
반응물 2
생성물 1
시약·촉매·용매 1
실험 절차
The title compound is prepared as described in Example 1 but using (2-chloro-4-imidazo[4,5-b]pyridin-3-yl-phenyl)-acetic acid (Step 16.1) and 4-[(3-dimethylamino-propyl)-methyl-amino]-3-trifluoromethyl-phenylamine (Step 5.1). Title compound: ES-MS: 544.9 [M+H]+; single peak at tR=3.66 min (System 1); Rf=0.28 (CH2Cl2/MeOH+1% NH3aq, 9:1).