Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Hydrazinobenzoic acid → 4-(5-Amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Hydrazinobenzoic acid | HCID 12089 | — |
| 반응물 | Pentanenitrile, 4,4-dimethyl-3-oxo- | HCID 108871 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-(5-Amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid | HCID 974688 | — |
반응 단계
To a suspension of 2.4 g (16 mmol) 4-hydrazino-benzoic acid in 12 mL toluene, 2.0 g of pivaloyl acetonitrile are added at rt. The suspension is heated to and kept under reflux for 12 h. After completion, the resulting reaction mixture is allowed to cool to rt. The precipitated product is isolated by filtration, washed with cold toluene and dried under high vacuum. [M+1]+=260.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08030311B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-cc0f4202c7ad45a6903e387b1dfd118c |
| 출처 메모 | uspto-grants-2011_10 |