4-Hydrazinobenzoic acid → 4-(5-Amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid

HRID 1661003

반응식

HRID 1661003 반응식
[NH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1)[NH2:2].[C:12]([CH2:18][C:19]#[N:20])(=O)[C:13]([CH3:16])([CH3:15])[CH3:14]>C1(C)C=CC=CC=1>[NH2:20][C:19]1[N:1]([C:3]2[CH:4]=[CH:5][C:6]([C:7]([OH:9])=[O:8])=[CH:10][CH:11]=2)[N:2]=[C:12]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:18]=1

참가 물질

4

반응물 2

HCID 120894-Hydrazinobenzoic acidHCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-

생성물 1

HCID 9746884-(5-Amino-3-tert-butyl-pyrazol-1-yl)-benzoic acid

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a suspension of 2.4 g (16 mmol) 4-hydrazino-benzoic acid in 12 mL toluene, 2.0 g of pivaloyl acetonitrile are added at rt. The suspension is heated to and kept under reflux for 12 h. After completion, the resulting reaction mixture is allowed to cool to rt. The precipitated product is isolated by filtration, washed with cold toluene and dried under high vacuum. [M+1]+=260.

후처리

  1. additionare added at rt
  2. temperatureThe suspension is heated to and
  3. temperatureunder reflux for 12 h
  4. customAfter completion, the resulting reaction mixture
  5. customThe precipitated product is isolated by filtration
  6. washwashed with cold toluene
  7. customdried under high vacuum

출처 및 근거

ORD 기록
ord-cc0f4202c7ad45a6903e387b1dfd118c
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030311B2

연결된 노트

불러오는 중…