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Sodium Iodide → 1-(4-(5-Fluoro-2,3-dihydrospiro[indene-1,3'-pyrrolidine]-1'-yl)butyl)-5-(thiophen-2-yl)pyrimidine-2,4(1h,3h)-dione hydrochloride

HRID 1661078
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HRID 1661078 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH:11]=[C:10]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)[C:9](=[O:17])[NH:8][C:7]1=[O:18].Cl.[F:20][C:21]1[CH:22]=[C:23]2[C:31](=[CH:32][CH:33]=1)[C:26]1([CH2:30][CH2:29][NH:28][CH2:27]1)[CH2:25][CH2:24]2.C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>O.CN1C(=O)CCC1>[ClH:1].[F:20][C:21]1[CH:22]=[C:23]2[C:31](=[CH:32][CH:33]=1)[C:26]1([CH2:30][CH2:29][N:28]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]3[CH:11]=[C:10]([C:12]4[S:13][CH:14]=[CH:15][CH:16]=4)[C:9](=[O:17])[NH:8][C:7]3=[O:18])[CH2:27]1)[CH2:25][CH2:24]2
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참가 물질

7

반응물 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 592339261-(4-chlorobutyl)-5-(thiophen-2-yl)pyrimidine-2,4(1H,3H)-dioneHCID 674294815-Fluoro-2,3-dihydrospiro[indene-1,3'-pyrrolidine]hydrochloride salt

생성물 1

HCID 674283101-(4-(5-Fluoro-2,3-dihydrospiro[indene-1,3'-pyrrolidine]-1'-yl)butyl)-5-(thiophen-2-yl)pyrimidine-2,4(1h,3h)-dione hydrochloride
수율 84%

시약·촉매·용매 2

HCID 962Water용매HCID 13387N-methyl-2-pyrrolidone용매

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온도
70 °C

실험 절차

A mixture of 1-(4-chlorobutyl)-5-(thiophen-2-yl)pyrimidine-2,4(1H,3H)-dione (Prep23, 50 mg, 0.18 mmol), 5-fluoro-2,3-dihydrospiro[indene-1,3′-pyrrolidine]hydrochloride salt (Prep14, 50 mg, 0.26 mmol), potassium carbonate (108 mg, 0.78 mmol), sodium iodide (108 mg, 0.72 mmol) and NMP (1 ml) was stirred at 70° C. overnight. The mixture was then diluted with water and extracted with ethyl acetate. The EA phase was evaporated and the crude purified by preparative TLC to give the free base of the title compound (72 mg). The compound was purified by preparative HPLC and treated with a 1N solution of HCl-ether and freeze-dried to give the title compound (30 mg, y=35%).

후처리

  1. extractionextracted with ethyl acetate
  2. customThe EA phase was evaporated
  3. customthe crude purified by preparative TLC

출처 및 근거

ORD 기록
ord-566d3ed1310d493cab32b7a8ecfc67f9
출처 데이터셋
uspto-grants-2011_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08030322B2

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