Water → N-Isopropyl-4'-nitrobiphenyl-4-sulfonamide

HRID 1661145노트

반응식

HRID 1661145 반응식
[CH:1]([NH2:4])([CH3:3])[CH3:2].[N+:5]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)([O-:7])=[O:6].O>CN(C=O)C>[CH:1]([NH:4][S:20]([C:17]1[CH:18]=[CH:19][C:14]([C:11]2[CH:12]=[CH:13][C:8]([N+:5]([O-:7])=[O:6])=[CH:9][CH:10]=2)=[CH:15][CH:16]=1)(=[O:21])=[O:22])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 6363IsopropylamineHCID 27601854'-Nitrobiphenyl-4-sulfonyl chloride

생성물 1

HCID 59694089N-Isopropyl-4'-nitrobiphenyl-4-sulfonamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

0.22 ml (2.52 mmol) of isopropylamine is added to a solution of 150 mg (0.50 mmol) of 4′-nitrobiphenyl-4-sulfonyl chloride in 2.0 ml of DMF. After 18 h at room temperature, 2.5 ml of water are added to the reaction mixture. The resulting precipitate is filtered off with suction and dried under high vacuum. 126 mg (64.4% of theory) of the title compound are obtained and reacted further without further purification.

후처리

  1. filtrationThe resulting precipitate is filtered off with suction
  2. customdried under high vacuum

출처 및 근거

ORD 기록
ord-a9db3679187148db82e1da1f2ab90eb8
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030329B2

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