Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropanol → (1R,2S)-2-amino-1-(quinolin-3-yl)propan-1-ol dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | Aluminum isopropoxide | HCID 11143 | — |
| 반응물 | (S)-tert-butyl 1-oxo-1-(quinolin-3-yl)propan-2-ylcarbamate | HCID 59339907 | — |
| 반응물 | (1R,2S)-2-amino-1-[4-(methylthio)phenyl]propan-1-ol hydrochloride | HCID 66688026 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | (1R,2S)-2-amino-1-(quinolin-3-yl)propan-1-ol dihydrochloride | HCID 66686852 | — |
반응 단계
Following the procedure described for preparation of 29b. Starting from (S)-tert-butyl 1-oxo-1-(quinolin-3-yl)propan-2-ylcarbamate (42c, 1.6 g, 5.33 mmol), Aluminium isopropoxide (0.68 g, 3.33 mmol) and 2-propanol (4.5 mL, 59.16 mmol) in toluene (7 mL) stirred at +50° C. in sealed reaction tube flushed with argon for 16 hours. Work up and deprotection of the intermediate BOC-protected amine afforded the subtitle compound as a colourless solid. Yield 1.29 g (88%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08030340B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-f573b2294e3f4745b3ae7fc31bcda453 |
| 출처 메모 | uspto-grants-2011_10 |