Thionyl Chloride → 2-Methoxypyridine-4-carbonyl chloride
반응식
S(Cl)([Cl:3])=O.[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][N:15]=1)[C:10](O)=[O:11]>C1(C)C=CC=CC=1>[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][N:15]=1)[C:10]([Cl:3])=[O:11]참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
Thionyl chloride (30.0 mL, 0.39 mol) was added to a suspension of 2-methoxy-isonicotinic acid (15.0 g, 97.9 mmol) in anhydrous toluene (150 mL). The mixture was heated at 80° C. under nitrogen for 3 hours, cooled to room temperature and filtered. The filtrate was concentrated in vacuo to afford the title compound 7.7 g (46% yield).
후처리
- temperaturecooled to room temperature
- filtrationfiltered
- concentrationThe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-fa87cee453c74028962bd64ba9e7a046
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08030500B2
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