Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1662222생성일: 2026년 10월 24일
Sodium Bicarbonate → N-((5-chloro-2-cyano-3-fluorophenyl)(3-methoxyphenyl)methylene)-2-methylpropane-2-sulfinamide
https://huagongshe.com/ko/reaction/1662222
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Tert-Butanesulfinamide | HCID 3382465 | — |
| 반응물 | 4-Chloro-2-fluoro-6-(3-methoxybenzoyl)benzonitrile | HCID 58579524 | — |
| 촉매 | Titanium tetraethoxide | HCID 76524 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-((5-chloro-2-cyano-3-fluorophenyl)(3-methoxyphenyl)methylene)-2-methylpropane-2-sulfinamide | HCID 76821604 | 59% |
반응 단계
4-Chloro-2-fluoro-6-(3-methoxybenzoyl)benzonitrile (2.56 g, 8.84 mmol), 2-methyl-2-propanesulfinamide (1.392 g, 11.49 mmol) and titanium(IV) ethoxide (4.62 mL, 22.09 mmol) were dissolved in THF (30 mL) and stirred at 75° C. over weekend. When cooled to rt, the mixture was diluted with DCM (25 mL). Saturated aqueous NaHCO3 (3 mL) was added followed by silica and the mixture concentrated under reduced pressure until a free flowing powder was obtained. Purification on a silica gel column (0-40% EtOAc in heptane as eluent) gave 2.04 g (59% yield) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08030500B2 |
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| 출처 데이터셋 | uspto-grants-2011_10 |
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| ORD ID | ord-751b48230fcf4f98beb5a0f168bc0b32 |
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| 출처 메모 | uspto-grants-2011_10 |
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