Pyridine, 4-methoxy-2-(tributylstannyl)- → 4-Fluoro-1-(3-(4-methoxypyridin-2-yl)phenyl)-1-(2-methoxypyridin-4-yl)-1H-isoindol-3-amine
반응식
Br[C:2]1[CH:3]=[C:4]([C:8]2([C:19]3[CH:24]=[CH:23][N:22]=[C:21]([O:25][CH3:26])[CH:20]=3)[C:16]3[C:11](=[C:12]([F:17])[CH:13]=[CH:14][CH:15]=3)[C:10]([NH2:18])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:27][O:28][C:29]1[CH:34]=[CH:33][N:32]=[C:31]([Sn](CCCC)(CCCC)CCCC)[CH:30]=1>>[F:17][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:11]=1[C:10]([NH2:18])=[N:9][C:8]2([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([C:31]2[CH:30]=[C:29]([O:28][CH3:27])[CH:34]=[CH:33][N:32]=2)[CH:3]=1)[C:19]1[CH:24]=[CH:23][N:22]=[C:21]([O:25][CH3:26])[CH:20]=1참가 물질
3
실험 절차
The title compound was synthesized as described in Example 29 in 13% yield starting from 1-(3-bromophenyl)-4-fluoro-1-(2-methoxypyridin-4-yl)-1H-isoindol-3-amine (0.150 g, 0.36 mmol) and 4-methoxy-2-(tributylstannyl)pyridine (0.188 g, 0.47 mmol).
출처 및 근거
- ORD 기록
- ord-c3ed224c420349fe912fd2a9b3288046
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08030500B2
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