Thionyl Chloride → 1-Bromo-4-(chloromethyl)-2-methylbenzene

HRID 1662309노트

반응식

HRID 1662309 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]O)=[CH:4][C:3]=1[CH3:10].S(Cl)([Cl:13])=O>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][Cl:13])=[CH:4][C:3]=1[CH3:10]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 10987288(4-Bromo-3-methylphenyl)methanol

생성물 1

HCID 189606101-Bromo-4-(chloromethyl)-2-methylbenzene수율 91.32%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 1.1 (2.0 g, 9.947 mmol) in DCM (50 mL) at 23° C. was added thionyl chloride (1.451 mL, 19.89 mmol) and allowed to stir overnight. The reaction was concentrated and then purified by combiflash (0 to 10% EtOAc/hexanes) to provide 1.2 (1.9940 g, 91.32% yield).

후처리

  1. concentrationThe reaction was concentrated
  2. custompurified by combiflash (0 to 10% EtOAc/hexanes)

출처 및 근거

ORD 기록
ord-f47f4f7a08054c05abdd60d670efe7bf
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030354B2

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