Thionyl Chloride → 2-Bromo-5-(chloromethyl)phenyl butyl ether

HRID 1662337노트

반응식

HRID 1662337 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]O)=[CH:4][C:3]=1[O:10][CH2:11][CH2:12][CH2:13][CH3:14].S(Cl)([Cl:17])=O>C(Cl)Cl>[CH2:11]([O:10][C:3]1[CH:4]=[C:5]([CH2:8][Cl:17])[CH:6]=[CH:7][C:2]=1[Br:1])[CH2:12][CH2:13][CH3:14]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 57705850(4-Bromo-3-(butyloxy)phenyl)methanol

생성물 1

HCID 577063052-Bromo-5-(chloromethyl)phenyl butyl ether수율 92%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 20.2 (659.3 mg, 2544 μmol) in DCM (15 mL) at 23° C., was added thionyl chloride (371 μL, 5088 μmol). The resulting mixture was stirred overnight. The reaction was concentrated and then purified by combiflash (0 to 10% EtOAc/Hexanes) to provide 20.3 (650 mg, 92.0% yield).

후처리

  1. concentrationThe reaction was concentrated
  2. custompurified by combiflash (0 to 10% EtOAc/Hexanes)

출처 및 근거

ORD 기록
ord-196a25fc8e724315a14d556eab312c94
출처 데이터셋
uspto-grants-2011_10
특허 번호
US08030354B2

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