(3-Methoxyphenyl)boronic acid → 3-[3-(3'-Methoxy-2-trifluoromethoxy-biphenyl-4-ylmethoxy)-phenyl]-propionic acid
반응식
Cl[C:2]1[CH:20]=[CH:19][C:5]([CH2:6][O:7][C:8]2[CH:9]=[C:10]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])[CH:11]=[CH:12][CH:13]=2)=[CH:4][C:3]=1[O:21][C:22]([F:25])([F:24])[F:23].[CH3:26][O:27][C:28]1[CH:29]=[C:30](B(O)O)[CH:31]=[CH:32][CH:33]=1>>[CH3:26][O:27][C:28]1[CH:33]=[C:32]([C:2]2[CH:20]=[CH:19][C:5]([CH2:6][O:7][C:8]3[CH:9]=[C:10]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])[CH:11]=[CH:12][CH:13]=3)=[CH:4][C:3]=2[O:21][C:22]([F:25])([F:24])[F:23])[CH:31]=[CH:30][CH:29]=1참가 물질
3
실험 절차
Compound 37 was synthesized using the procedure above for preparing 13.3 using compound 37.3 and 3-methoxyphenylboronic acid 37.4 (available from Aldrich). MS ESI (neg.) m/e: 445 (M−H). 1H NMR (400 MHz, CD3CN) δ ppm 7.51 (3H, s), 7.38 (1H, s), 7.22 (1H, s), 7.05 (2H, s), 6.98 (1H, s), 6.87 (3H, s), 5.15 (2H, s), 3.81 (3H, s), 2.86 (2H, s), 2.59 (2H, s).
출처 및 근거
- ORD 기록
- ord-0d78d63d3c9b4c1e8b21181a2835e8e2
- 출처 데이터셋
- uspto-grants-2011_10