Ethyl Acetate → HCID 19080443, 화합물
반응식
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[CH:12]=[C:13]([CH3:15])[CH3:14].CCOC(C)=O>[Pd]>[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[CH2:12][CH:13]([CH3:15])[CH3:14]참가 물질
4
실험 절차
To a stirred solution of methyl 4-hydroxy-3-(2-methylprop-1-enyl)benzoate 66.20B (0.320 g, 1.6 mmol) in EtOAc (2.00 mL, 20 mmol) at 23° C. was added palladium on carbon (0.017 g, 0.16 mmol). The reaction was stirred under an atmosphere of hydrogen (0.0031 g, 1.6 mmol) for 16 hours. The reaction mixture was then filtered and concentrated in vacuo to give a clear oil. The residue was purified on silica gel (0-20% EtOAc in hexanes) to yield 66.20C as a colorless oil (0.256 g, 79% yield)
후처리
- filtrationThe reaction mixture was then filtered
- concentrationconcentrated in vacuo
- customto give a clear oil
- customThe residue was purified on silica gel (0-20% EtOAc in hexanes)
출처 및 근거
- ORD 기록
- ord-753b42a4b0a0428ebfb14b822e109a5f
- 출처 데이터셋
- uspto-grants-2011_10
- 특허 번호
- US08030354B2
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